Amit is prescribed for the treatment of:
Always take medication under the supervision of a registered physician.
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Amit contains Amitriptyline, a tricyclic antidepressant (TCA) known for its sedative and anticholinergic effects. It works by inhibiting the reuptake of neurotransmitters such as noradrenaline and serotonin, enhancing their levels in the brain. The drug is quickly absorbed through the gastrointestinal tract, reaching peak plasma levels within 2 to 12 hours, and is mainly excreted via urine in the form of metabolites.
Although the exact mechanism is not fully understood, Amitriptyline is thought to act by blocking the membrane pump responsible for the reuptake of serotonin and norepinephrine in the central nervous system. This results in increased availability of these mood-regulating neurotransmitters at the synaptic cleft, which is believed to alleviate depressive symptoms. Its pain-relieving effects may or may not be directly related to its antidepressant action.
Anticholinergic:
Cardiovascular:
Neurological:
Allergic Reactions:
Hematologic:
Gastrointestinal:
Endocrine:
Depression
Adults: Start with 75 mg daily, divided or taken as a single dose at bedtime. Adjust gradually up to 150–200 mg/day based on response.
Elderly and Adolescents: 30–75 mg/day
Not recommended in children under 16 for depression.
Nocturnal Enuresis (bedwetting)
Age 7–10: 10–20 mg at bedtime
Age 11–16: 25–50 mg at bedtime
Maximum treatment duration, including tapering, is 3 months. A thorough exam is required before repeat therapy.
Migraine Prevention: 100 mg once daily
Tension Headache: 10–25 mg three times daily
Always follow physician's dosage instructions.
May enhance sedation caused by alcohol or opioid medications
Increased risk of cardiac arrhythmias when combined with drugs like moxifloxacin or terfenadine
Disulfiram and cimetidine slow down Amit’s metabolism
Diuretics may increase the risk of postural hypotension when used with Amitriptyline
Sedation may impair the ability to drive or use machinery, particularly at treatment initiation
Pregnancy Category C: May pose risks to the fetus; should be used only if necessary.
Amitriptyline is excreted into breast milk, and caution is advised. If treatment is essential, consider discontinuing breastfeeding or the drug, depending on maternal needs.
Store below 30°C in a cool, dry environment. Keep away from light and moisture.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.